Simafex’s core activity is the custom synthesis of pharmaceutical intermediates and active ingredients.

All classical reactions, even those involving the handling of reagents requiring particularly careful attention, can be conducted in our multi-purpose facilities.


We have a particular expertise in the following areas:

Oxydation
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DDQ
Diacetoxy Iodobenzene
SIBX (Stabilised IBX a reagent
with similar properties
to the Dess Martin Periodinane)
 
Iodination
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Diacetoxy Iodobenzene
Selective iodination technologies
for the production of key-intermediates
for coupling reactions (e.g. Heck)
Diazotation including Sandmeyer reaction
Selective aromatic iodination (Iodine monochloride or N-Iodosuccinimide.)
 
Alkylation
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Alkyl iodides, dimethyl sulfate
 
Cyanation
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• 
•
Handling of NaCN
HCN produced in situ
Strecker synthesis
 
Cyclopropanation
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TMSOI: Corey-Chaykovsky
Simmons-Smith reaction performed with diiodomethane or chloroiodomethane
 
Dehydrogenation of steroids
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DDQ
 
Epoxidation
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TMSOI
Chloroiodomethane
 
Organometallic chemistry
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Butyl lithium
L.D.A.
Grignard Reactions
 
Palladium coupling
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Suzuki
Pd2 (dba)3
 
Hydride chemistry
• 
LiAlH4, NaBH4, NaH…

Chiral synthesis
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Resolution
Chiral pool

Macrocyclisation
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Polyazamacrocycles
(Cyclen, Cyclam, Triclen)
Cyclodextrines